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目的探讨生殖异常与染色体异常的关系。方法检测180例生殖异常患者外周血淋巴细胞染色体核型。结果180例有不孕不育、畸形、死胎、习惯性流产患者染色体检查出异常核型13例,其中4例克氏综合征(K linefelter综合征),3例平衡易位,3例罗伯逊易位,2例臂间倒位,1例大Y染色体。结论染色体异常是导致不孕不育及自发流产的重要原因之一,对生殖异常患者进行染色体检查可为临床诊断和优生优育提供依据。
Objective To investigate the relationship between genital abnormalities and chromosomal abnormalities. Methods Totally 180 cases of genital abnormalities in peripheral blood lymphocytes chromosome karyotype. Results Of the 180 cases with infertility, deformity, stillbirth and habitual abortion, 13 cases were detected by chromosomal abnormalities, including 4 cases of K linefelter syndrome, 3 cases of balanced translocation and 3 cases of Robertson Bit, 2 cases of arm inversion, 1 case of large Y chromosome. Conclusion Chromosomal abnormalities are one of the most important causes of infertility and spontaneous abortion. Chromosome examination in patients with genital abnormalities may provide evidence for clinical diagnosis and prenatal and postnatal care.