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目的 :探讨缺氧刺激对血清红细胞生成素 (EPO)和转铁蛋白受体 (sTfR)的影响 ,观察在低氧刺激环境下血液EPO分泌和血清sTfR浓度的变化规律。方法 :受试者为 2 0名身体健康的男性大学生 ,随机分为 3组 :间歇吸低氧组 (n =7)、模拟高住组 (n =5 )和对照组 (n =8)。间歇吸低氧组每天 30分钟吸低氧 ,模拟高住组每天 8小时低氧环境睡眠。所有受试者在实验期均从事相同的体育技术课和理论课学习及相同的生活作息 ,全部实验共包括 4周试验期和 2周恢复期。结果 :(1)对照组血清EPO浓度在实验前、中和恢复期均无明显变化。间歇吸低氧组血清EPO浓度在实验第 3天、第 17天、第 2 2天 ,模拟高住组血清EPO浓度在实验第 15天、第 17天、第 2 2天、第 2 4天及恢复期均显著高于实验前 (P <0 0 5 ) ,(2 )间歇吸低氧组血清sTfR浓度在实验第 3天、第 10天、第 17天及恢复期结束均显著高于实验前 (P <0 0 5 ) ,而模拟高住组和对照组血清sTfR浓度在实验期和恢复期均未发生明显变化。 (3)实验后间歇吸低氧组受试者VO2 max与实验前比较明显增加(P <0 0 5 )。 (4)除对照组外 ,实验后间歇吸低氧组、模拟高住组在定量负荷运动中的心率、血乳酸与实验前相比显著下降 (P <0 0 5 )。结论 :血清EPO、sTfR浓度的变化受不同低氧浓度刺
OBJECTIVE: To investigate the effects of hypoxia on serum erythropoietin (EPO) and transferrin receptor (sTfR) and to investigate the changes of blood EPO secretion and serum sTfR concentration under hypoxic conditions. Methods: Twenty healthy male college students were randomly divided into 3 groups: intermittent hypoxia (n = 7), simulated high-survival group (n = 5) and control group (n = 8). Intermittent hypoxia group 30 minutes a day hypoxia, simulated high-housing group 8 hours a day hypoxic environment sleep. All subjects in the experimental period are engaged in the same physical education class and theory classes and the same life and work, all experiments include a total of 4 weeks trial period and 2 weeks recovery period. Results: (1) There was no significant change in serum EPO concentrations in the control group before, during and after the experiment. Intermittent hypoxia group serum EPO concentration in the experimental day 3, day 17, day 22, the simulation of high EPO serum EPO concentrations in the experimental day 15, day 17, day 22, day 24 and (2) The concentration of sTfR in intermittent hypoxia group was significantly higher than that before experiment on the 3rd, 10th, 17th day and the end of convalescence (P <0.05). However, there was no significant change in serum sTfR concentration between experimental and convalescent groups. (3) The VO2max of intermittent hypoxia group increased significantly after the experiment (P <0.05). (4) In addition to the control group, the hypoxia group was intermittently inhaled after the experiment to simulate the heart rate during high-load exercise, and the blood lactate decreased significantly compared with that before the experiment (P <0.05). Conclusion: The changes of serum EPO and sTfR concentrations are stimulated by different hypoxia concentrations