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目的 :检测慢性胃炎各阶段黏膜细胞凋亡状况及探讨其意义。方法 :用TUNEL法检测 6例正常胃黏膜、5 4例慢性浅表性胃炎 (CSG)及 2 8例慢性萎缩性胃炎 (CAG)患者胃黏膜上皮细胞凋亡状况。结果 :凋亡指数(AI)CSG >CAG >正常胃黏膜 (P <0 .0 5 ) ,而且炎症黏膜凋亡细胞分布与正常有所不同 ;在CAG ,AI在肠化区 <非肠化区。结论 :细胞凋亡在CAG黏膜萎缩及肠化发生中起重要作用。CAG黏膜AI下降可能与胃癌发生有关。
Objective: To detect the apoptosis of mucosal cells in all stages of chronic gastritis and to explore its significance. Methods: TUNEL method was used to detect the gastric mucosal epithelial cell apoptosis in 6 cases of normal gastric mucosa, 54 cases of chronic superficial gastritis (CSG) and 28 cases of chronic atrophic gastritis (CAG). Results: Apoptosis index (AI) CSG> CAG> normal gastric mucosa (P <0.05), and the distribution of apoptotic cells in inflammatory mucosa was different from normal. . Conclusion: Apoptosis plays an important role in mucosal atrophy and intestinal metaplasia. Decreased CAG mucosal AI may be related to the occurrence of gastric cancer.