混合性结缔组织病(MCTD)较少见,常见症状有多发性关节病,指(趾)硬皮病,双手浮肿,肌炎,食道蠕动减慢及雷诺氏现象,也可出现口腔症状,但引起舌的改变未见报道。现报道一例。患者女,60岁,吞嚥困难,食物反流入鼻腔,双腿部近端肌肉无力2个月,并有双手疼痛,早晨四肢强直和雷诺氏现象。5年前做胆囊切除术,同时发现肝脏异常,局部活检为结核性干酪型肉芽肿。术后以链霉素、雷米封、利福平治疗效果满意。查体:双手指硬皮病和类风湿样改变,肢体无触痛,近端肌肉明显无力,腱 Mixed connective tissue disease (MCTD) is rare, common symptoms include multiple joint disease, finger (toe) scleroderma, edema of both hands, myositis, slowing of esophageal motility, and Raynaud’s phenomenon. Oral symptoms may also occur. No change in the tongue has been reported. One case is reported. The female patient, 60 years old, had difficulty in swallowing, and the food flowed back into the nasal cavity. The muscles in the proximal legs of the legs were weak for two months. There was pain in both hands, and the rigidity of the limbs and Raynaud’s phenomenon in the morning. Cholecystectomy was performed 5 years ago. Hepatic abnormalities were found. Local biopsy was tuberculous granuloma. After the treatment with streptomycin, Ramiban, rifampicin treatment effect is satisfactory. Physical examination: Scleroderma and rheumatoid-like changes in both fingers, no tenderness in the limbs, apparent weakness in proximal muscles, paralysis