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目的 运用22MHz高频超声对银屑病指甲改变进行观测并分析.方法 收集江苏省中医院皮肤科合并有指甲改变的银屑病患者80例,分别用皮肤镜和高频超声对指甲进行观察,并进行统计分析.结果 皮肤镜对银屑病甲的检出率为60.50％,高频超声为63.25％,两种方法差异无统计学意义(P＞0.05).对于甲板增厚及甲角化过度方面,两者的检出率差异无统计学意义(P＞0.05),而对于甲营养不良和银屑病浸润方面,高频超声的检出率高于皮肤镜(P＜0.05).同时高频超声具有高分辨率等优点.结论 高频超声对于银屑病甲的诊断有重要价值.“,”Objective To explore the changes of nails with psoriasis by 22MHz high-frequency ultrasonography.Methods Eighty cases of patients with psoriasis with changes of nails were enrolled in the dermatological department of Jiangsu Province Hospital of Traditional Chinese Medicine.Changes of nails were observed with dermatoscope and high frequency ultrasonography separately.Results The detection rate of dermatoscope was 60.50％,and the detection rate of high frequency ultrasonography was 63.25％.There were no significant statistical difference between the two methods (P ＞ 0.05).As to pachyonychia and subungual hyperkeratosis,there were also no significant statistical difference between the two methods(P ＞ 0.05).Nevertheless as to nail dystrophy and psoriasis infiltration,the detection rate of high frequency ultrasonography was higher than dermatoscope (P ＜ 0.05).And the high-frequency ultrasonography had the advantage of high resolution.Conclusion High frequency ultrasonography had important value for the diagnosis of nail changes with psoriasis.