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目的探讨T2DM伴颈动脉硬化(CAC)患者动态血糖波动的特点。方法 88例受试者分T2DM伴颈动脉硬化(CAC)组38例,T2DM无颈动脉硬化(NCAC)组35例和正常对照(NC)组15例,采用动态血糖监测系统(CGMS)监测三组72h血糖变化,计算日内平均血糖波动幅度(MAGE)和血糖波动系数(BGFC)。计算胰岛素抵抗指数HOMA-IR,对相关数据进行对比分析。结果 CAC组BGFC、MAGE及HOMA-IR明显高于NCAC组(P均<0.05);CAC组颈动脉内中膜厚度(IMT)与BGFC、MAGE及HOMA-IR呈正相关(r分别为0.352、0.360、0.336,P均<0.05);CAC组BGFC、MAGE与HOMA-IR呈正相关(r分别为0.341、0.362,P均<0.05)。结论 2型糖尿病颈动脉硬化与血糖波动相关,血糖波动可能促进了颈动脉硬化的发生与发展。
Objective To investigate the characteristics of dynamic blood sugar fluctuation in patients with T2DM and carotid atherosclerosis (CAC). Methods Eighty - eight subjects were divided into two groups: 38 cases in T2DM group with carotid atherosclerosis (CAC), 35 cases in T2DM without carotid atherosclerosis group (NCAC) and 15 cases in NC group. The dynamic monitoring of blood glucose (CGMS) Group 72h blood glucose changes, calculate the average daily blood glucose fluctuation (MAGE) and blood glucose fluctuation coefficient (BGFC). Calculate insulin resistance index HOMA-IR, comparative analysis of the relevant data. Results The levels of BGFC, MAGE and HOMA-IR in CAC group were significantly higher than those in NCAC group (all P <0.05). The carotid intima-media thickness (IMT) was positively correlated with BGFC, MAGE and HOMA-IR in CAC group (r = 0.352, , 0.336, P <0.05). There was a positive correlation between BGCAC, MAGE and HOMA-IR in CAC group (r = 0.341,0.362, P <0.05). Conclusions Carotid atherosclerosis in type 2 diabetes is associated with fluctuations in blood glucose, and fluctuations in blood glucose may contribute to the development of carotid atherosclerosis.