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目的:探讨通痹饮合剂治疗类风湿性关节炎的作用。方法:建立Freund`s完全佐剂性大鼠关节炎模型,观察通痹饮合剂对大鼠关节肿胀度、血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平。结果:通痹饮合剂低、高剂量对大鼠Freund`s完全佐剂性关节炎的继发性足跖肿胀度均有显著的抑制作用(P<0.05,或P<0.01),可抑制IL-1β、TNF-α的异常升高(P<0.05,P<0.05)。结论:肾通痹片可能通过降低佐剂性关节炎大鼠血清中异常增高的IL-1β、TNF-α浓度而发挥抗类风湿关节炎的作用。
Objective: To investigate the effect of tongbi decoction on rheumatoid arthritis. Methods: Freund’s complete adjuvant arthritis model was established in rats. The effects of Tongbi decoction on the degree of joint swelling, serum levels of IL-1β, TNF-α, Level. Results: Tongbi Decoction low and high doses significantly inhibited the degree of secondary plantar swelling in Freund’s complete adjuvant arthritis rats (P <0.05 or P <0.01), and inhibited IL -1β and TNF-α (P <0.05, P <0.05). Conclusion: JST could play an anti-rheumatoid arthritis effect by decreasing the abnormally elevated IL-1β and TNF-α levels in serum of adjuvant arthritis rats.