血友病是临床上最常见的遗传性出血性疾病,临床主要表现为关节、肌肉和深部组织自发性或轻微外伤后出血难止,若不及时治疗可导致关节畸形和假肿瘤等,严重者可危及生命。男性中发病率约10~20/10万,而女性血友病患者极其罕见,因其关节/肌肉反复出血,大部分患者最终出现关节畸形、肌肉萎缩等并发症,同时,因自发性出血,患者活动减少 Hemophilia is the most common hereditary hemorrhagic disease in clinic. The main clinical manifestations are bleeding from joints, muscles and deep tissues after spontaneous or minor trauma. If not treated in time, it can lead to joint deformities and false tumors. In severe cases, Can be life threatening. The incidence of males is about 10 ~ 20/100000, while women with hemophilia are extremely rare, because of repeated bleeding in their joints / muscles, most patients eventually have complications such as joint deformities and muscle atrophy. At the same time, due to spontaneous bleeding, Reduced patient activity