The aim of this research was to examine the effect of microstructural parameters on the tensile properties of different compositions of tungsten heavy alloys. The microstructural parameters (grain size, connectivity, contiguity, and solid volume fraction) were measured and were found to have a significant effect on the tensile properties of tungsten-based heavy alloys. The microstructural parameters of W-Ni-Fe alloys are sufficiently different to present a range of mechanical properties. It is concluded that the mechanical properties of tungsten heavy alloys largely depend on the microstructural parameters and their ductility is particularly harmed when grains are contiguous.