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目的运用Meta分析方法综合评价CXCL12 rs1801157基因多态性与肿瘤发病的关系。方法通过计算机检索和手工检索,收集有关CXCL12 rs1801157基因多态性与肿瘤易感性关系的文献,筛选出符合条件的文献,运用Meta分析方法对各项研究进行异质性检验后计算合并OR值及其95%可信区间,并进行敏感性分析及发表偏倚的评估。结果 15篇符合条件的文献纳入本研究,累积病例组3 225例,对照组4 001例。Meta分析合并结果显示突变等位基因A携带者相比野生等位基因G携带者肿瘤发病风险显著提高,合并值OR=1.27 95%CI=1.12～1.43,差异有统计学意义(P<0.01);基因型AA∶GG,GA∶GG和(AA+GA)∶GG合并OR值及其95%可信区间分别是1.30,95%CI=1.05～1.61、1.45,95%CI=1.22～1.72和1.43,95%CI=1.21～1.68,差异均有统计学意义。按肿瘤类型进行分层,A等位基因携带者相比G等位基因携带者显著提高乳腺癌发病(OR=1.32,95%CI=1.15～1.51,P<0.01);AA∶GG,GA∶GG和(AA+GA)∶GG合并OR值及其95%可信区间分别是1.64,95%CI=1.16～2.33、1.42,95%CI=1.18～1.70和1.44,95%CI=1.21～1.72。结论 CXCL12 rs1801157基因多态性与肿瘤易感性有关,突变等位基因A与肿瘤易感性升高有关,基因型AA或基因型GA携带者相对基因型GG携带者肿瘤发病风险提高。突变等位基因A增加乳腺癌易感性。
Objective To evaluate the relationship between CXCL12 rs1801157 polymorphism and tumor progression by Meta-analysis. Methods The literature about the relationship between CXCL12 rs1801157 gene polymorphism and tumor susceptibility was collected by computer searching and manual searching. The eligible literatures were screened out. Meta analysis was used to examine the heterogeneity of each study and the combined OR was calculated. Its 95% confidence interval, and sensitivity analysis and publication bias assessment. Results Fifteen eligible articles were included in the study, with 3 225 cumulative cases and 4 001 control subjects. Meta-analysis results showed that the mutation allele A carriers significantly increased the risk of tumor development compared with the wild-type G carriers, the combined value was 1.27 95% CI = 1.12-1.43, the difference was statistically significant (P <0.01) ; Genotypes AA: GG, GA: GG and (AA + GA): GG combined OR and their 95% confidence intervals were 1.30, 95% CI = 1.05-1.61, 1.45, 95% CI = 1.22-1.72 and 1.43, 95% CI = 1.21 ~ 1.68, the differences were statistically significant. According to the type of tumor, A allele carriers significantly increased breast cancer incidence compared with G allele carriers (OR = 1.32, 95% CI = 1.15-1.51, P <0.01); AA: GG, GA: GG and (AA + GA): GG combined OR values and their 95% confidence intervals were 1.64, 95% CI = 1.16 to 2.33, 1.42, 95% CI = 1.18 to 1.70 and 1.44, 95% CI = 1.21 to 1.72 . Conclusions CXCL12 rs1801157 gene polymorphism is associated with tumor susceptibility. Mutation allele A is associated with an increased susceptibility to cancer. Genotype AA or genotype GA carriers may increase the incidence of oncogenic tumors in GG carriers. Mutation of allele A increases breast cancer susceptibility.