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目的:观察自体骨髓间充质干细胞(BMSC)移植治疗合并不同并发症的失代偿期肝硬化的临床效果。方法:回顾性分析我院自2008年12月至2013年12月收治的148例经自体BMSC移植治疗的肝硬化合并肝性脑病、肝肾综合征、肝源性糖尿病以及消化道出血患者治疗前后的肝、肾功能、血清蛋白、血常规等指标的变化情况。结果:治疗后,肝硬化合并肝性脑病患者的ALT、血氨水平改善明显,TBIL反复;合并肝肾综合征的患者HB、Crea水平改善明显,ALT、AST、DBIL反复;合并肝源性糖尿病患者的ALT、TBIL、DBIL、TB、ALB、血糖水平改善明显;合并消化道出血患者的ALT、TP、ALB改善明显,AST、TBIL、PLT反复。结论:自体BMSC移植治疗肝硬化合并肝源性糖尿病的效果较好,对合并肝性脑病、肝肾综合征以及消化道出血患者的效果欠佳。
Objective: To observe the clinical effect of autologous bone marrow mesenchymal stem cells (BMSC) transplantation in the treatment of decompensated cirrhosis with different complications. Methods: A retrospective analysis of 148 patients with cirrhosis with hepatic encephalopathy, hepatorenal syndrome, liver-derived diabetes mellitus and gastrointestinal bleeding treated with autologous BMSC in our hospital from December 2008 to December 2013 was retrospectively analyzed. The liver, kidney function, serum protein, blood and other indicators of changes. Results: After treatment, ALT and serum ammonia levels were significantly improved in patients with cirrhosis and hepatic encephalopathy, TBIL was repeated; HBeAg and Crea levels were significantly improved in patients with hepatorenal syndrome, ALT, AST and DBIL were repeated; Patients with ALT, TBIL, DBIL, TB, ALB, blood glucose levels improved significantly; patients with gastrointestinal bleeding ALT, TP, ALB improved significantly, AST, TBIL, PLT repeated. CONCLUSIONS: Autologous BMSC transplantation has a good effect in the treatment of cirrhosis and liver-derived diabetes mellitus, and its effect on patients with hepatic encephalopathy, hepatorenal syndrome and gastrointestinal bleeding is poor.