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目的 :通过监测分析 ,掌握全省肾综合征出血热 (HFRS)流行规律 ,控制暴发流行 ,进一步降低发病率 ,制订防制措施。方法 :采用直接免疫荧光法 (FAT)检测鼠肺HV抗原 ;采用间接免疫荧光法 (IFAT)检测HFRS病人、健康人血清以及鼠血中HV抗体。结果 :1997～ 1999年全省共发病 75 34例 ,年均发病率为 5 .6 5 / 10万 ,死亡 39人 ,病死率为 0 .5 2 %。病例仍主要分布在沿钱塘江两岸的浙东和浙西丘陵区 ,浙南山区次之 ,浙北平原区和海岛区病例较少 ;全省 11个地市 (除舟山以外 )均有发病 ,以浙东和浙西丘陵区的绍兴、宁波、台州、衢州、杭州和金华 6市发病最多 ,占全省病例总数的 87.44 %。宿主动物野外以黑线姬鼠为优势种 ,占 80 .2 4% ;室内以褐家鼠为优势种 ,占 85 .0 0 %。结论 :进一步加大监测力度及接种HFRS疫苗 ,是控制该病的有效措施
OBJECTIVE: To monitor and analyze the prevalence of hemorrhagic fever with renal syndrome (HFRS) in the province, and to control the outbreak of epidemics so as to further reduce the incidence and make prevention measures. Methods: The mouse lung HV antigen was detected by direct immunofluorescence (FAT). The HV antibodies of HFRS, healthy human and mouse blood were detected by indirect immunofluorescence assay (IFAT). Results: From 1997 to 1999, a total of 75 34 cases were found in the province with an average annual incidence rate of 5.66 / 100 000 and 39 deaths with a mortality rate of 0.52%. The cases are still mainly distributed in the eastern and western Zhejiang hilly areas along the banks of the Qiantang River, followed by the mountainous areas in the southern Zhejiang and the plain areas in the northern Zhejiang and island areas. There are 11 cities in the province except Zhoushan, The most incidences were in Shaoxing, Ningbo, Taizhou, Quzhou, Hangzhou and Jinhua in hilly areas of eastern Zhejiang and western Zhejiang, accounting for 87.44% of the total cases in the province. Host animals in the wild Apodemus heterophylla as the dominant species, accounting for 80.24%; indoors to Rattus norvegicus dominant species, accounting for 85.0%. Conclusion: To further intensify the monitoring and vaccination of HFRS vaccine is an effective measure to control the disease