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肾综合征出血热(HFRS)类的疾病在苏联、中国、东欧、日本和斯堪的那维亚已有广泛报导。1940年苏联通过在志愿者身上的传代试验证实,本病为病毒性传染。自此四十多年后才明确朝鲜出血热的致病因子——汉坦病毒为布尼亚病毒科的一个新属(汉病毒属)中的病毒。在亚洲国家,病例普遍为重型。欧洲大部分病例为轻型,然而保加利亚和匈牙利的临床报告提示存在着和亚洲东部病型相似,有高死亡率(18％)的重型病例。血清学及病毒学证实了这些发现。比利时和法国最近报导了和斯堪的那维亚流行性肾病(NE)有关系的几例轻
Hemorrhagic fever with renal syndrome (HFRS) -like diseases have been widely reported in the Soviet Union, China, Eastern Europe, Japan and Scandinavia. In 1940 the Soviet Union passed the passage test on volunteers to confirm that the disease was viral. Since more than 40 years later, it has been clarified that the causative agent of haemorrhagic fever in North Korea - the Hantaan virus is a virus in a new genus (Han Viroid) of the Bunyaviridae family. In Asian countries, cases are generally heavy. The majority of cases in Europe are light, however, clinical reports from Bulgaria and Hungary suggest that there are heavy cases with similar high mortality rates (18%) similar to eastern Asia. Serology and virology confirmed these findings. Belgium and France recently reported several cases of light-related nephropathy (NE) in Scandinavia