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硫酸镁注射,具有抗惊厥、降血压之功效,常用于子痫、破伤风及高血压危象的治疗;但若使用不当,血镁浓度过高就可发生呼吸麻痹(甚至死亡),临床则以静注钙剂对抗,多可转危为安。今就Ca~(++)-Mg~(++)对抗的原理及其临床意义作一概述。一、镁的生理、生化和药理作用 Mg~(++)在细胞内液中的含量仅次子K~+,为机体所必需。成人(体重70 kg)体内含镁约2 000 mEq/L,血镁浓度一般为1.5～2.2 mEq/L,其中2/3呈离子状态,1/3与血浆蛋白结合。Mg~(++)参与多种生理生化过程,表现一定的特性。
Magnesium sulfate injection, with anticonvulsant, lower blood pressure effect, commonly used in the treatment of eclampsia, tetanus and hypertensive crisis; but if used improperly, blood magnesium concentration can occur respiratory paralysis (or even death), the clinical Calcium confrontation confrontation, and more can turn crisp. This article summarizes the principle of Ca ~ (++) - Mg ~ (++) antagonism and its clinical significance. First, the physiological, biochemical and pharmacological effects of magnesium Mg ~ (++) in the intracellular fluid content of only the second K ~ +, is necessary for the body. Adult (70 kg body weight) contains about 2,000 mEq / L of magnesium and typically has a serum magnesium concentration of 1.5-2.2 mEq / L, of which two thirds are ionized and one third are bound to plasma proteins. Mg ~ (++) participates in a variety of physiological and biochemical processes, showing certain characteristics.