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我们对168例60岁以上老年人临床上有打鼾或肥胖者进行多导仪监测夜间睡眠呼吸,确诊为睡眠呼吸暂停综合征(SAS)96例,其中合并冠心病者53例,占55.2%。排除SAS 72例,但患有冠心病者11例,占15.3%。两组比较有显著性差异(P<0.01)。在 SAS 合并冠心病者中,39例夜间发生心肌缺血,其中29例发生在 SaO_2<90%,10例发生在 SaO_2>90%时,两组比较差异显著(P<0.05)。因 SAS 可引起低氧血症和高碳酸血症,血液动力学改变,冠脉血氧含量降低导致血管内皮损伤,促进冠状动脉硬化的形成及心肌缺血的发生。因此,SAS 可能促进冠心病的发生。
We conducted a total of 168 cases of sleep apnea syndrome (SAS) diagnosed as sleep apnea syndrome (SAS) in 168 cases of snoring or obesity who were clinically suffering from snoring or obesity over the age of 60. Fifty-three patients (55.2%) had coronary heart disease. 72 cases were excluded from SAS, but 11 cases had coronary heart disease, accounting for 15.3%. There was significant difference between the two groups (P <0.01). In SAS patients with coronary heart disease, 39 patients had myocardial ischemia at night, of which 29 cases occurred in SaO_2 <90%, 10 cases occurred in SaO_2> 90%, there was significant difference between the two groups (P <0.05). Because SAS can cause hypoxemia and hypercapnia, hemodynamic changes, decreased coronary blood lead to vascular endothelial injury, promote the formation of coronary atherosclerosis and myocardial ischemia. Therefore, SAS may promote the occurrence of coronary heart disease.