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目的初步探讨高血压病患者的阿司匹林抵抗(AR)情况及其与血栓素B2(TXB2)和6-酮前列腺素F1α(6-K-PGF1α)的关系。方法88例高血压病患者服用阿司匹林100 mg/d≥1周后,分别用花生四烯酸(AA)、二磷酸腺苷(ADP)作诱导剂检测血小板聚集率(PAG),并测定血浆TXB2和6-K-PGF1α浓度。AA诱导的血小板平均聚集率≥20%,同时ADP诱导的血小板平均聚集率≥70%者为AR;仅符合其中一项为阿司匹林半抵抗(ASR);均不符合者为阿司匹林敏感(AS)。结果88例高血压病患者AR发生率为17.05%(15例),ASR发生率是18.18%(16例)。血浆TXB2浓度与AA诱导的PAG呈正相关(r=0.437,P<0.001),血浆6-K-PGF1α浓度与AA诱导的PAG呈正相关(r=0.388,P<0.001),与ADP诱导的PAG呈正相关(r=0.361,P<0.001)。AR和ASR患者血浆TXB2浓度、lg(6-K-PGF1α)高于AS患者,差异有统计学意义(分别P<0.05)。结论高血压病患者AR+ASR发生率为35.23%;AR或ASR患者血浆TXB2和6-K-PGF1α浓度较高。
Objective To investigate the relationship between aspirin resistance (AR) and thromboxane B2 (TXB2) and 6-ketoprostaglandin F1α (6-K-PGF1α) in hypertensive patients. Methods Eighty-eight patients with hypertension were given aspirin 100 mg / d for more than one week. The concentrations of platelet aggregation (PAG) were measured with arachidonic acid (AA) and adenosine diphosphate (ADP) And 6-K-PGF1α concentration. AA induced platelet aggregation rate ≥20%, ADP induced platelet aggregation rate ≥70% were AR; only one of them was aspirin half-resistance (ASR); none of the patients were aspirin-sensitive (AS). Results The incidence of AR in 88 patients with hypertension was 17.05% (15 cases), and the incidence of ASR was 18.18% (16 cases). There was a positive correlation between plasma concentration of TXB2 and PAG induced by AA (r = 0.437, P <0.001). Plasma 6-K-PGF1α concentration was positively correlated with AA induced PAG (r = 0.388, P <0.001) (R = 0.361, P <0.001). The levels of plasma TXB2 and lg (6-K-PGF1α) in patients with AR and ASR were significantly higher than those in patients with AS (P <0.05, respectively). Conclusions The incidence of AR + ASR in hypertension patients is 35.23%. The concentrations of TXB2 and 6-K-PGF1α in patients with AR or ASR are higher.