异名 Zavedos,Idamycin 化学名 4-去甲氧基-柔红霉素药效分类抗癌药开发单位 (英)Farmitalia Carlo Erba公司上市厂商 (英)Farmitalia公司 1990年在英国上市药理本品的蒽环结构上第4位没有甲氧基,因而亲脂性比柔红霉素强,细胞的吸收速率也较快。本品的细胞毒性是柔红霉素的10倍,对培养的人肿瘤细胞的活性也比柔红霉素或阿霉素强。本品的初级代谢物依达比醇(4-去甲氧基-柔红霉醇)在体外的活性与依达比星相似。本品和代谢物静脉注射或口 Synonyms Zavedos, Idamycin Chemical name 4-methoxy-daunorubicin Pharmacodynamic Category Anti-Cancer Drug Development Unit (UK) Farmitalia Carlo Erba Listed Company (UK) Farmitalia Company Listed in the United Kingdom in 1990 the anthracene The 4th ring structure no methoxy, lipophilic and daunorubicin so strong, the absorption rate of cells faster. The cytotoxicity of this product is 10 times of daunorubicin, the activity of cultured human tumor cells is also stronger than daunorubicin or doxorubicin. The primary metabolites of this product, edabiol (4-demethoxy-daunorubicin), have similar in vitro activity to edaravir. This product and metabolites intravenous injection or mouth