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目的:探讨冠脉钙化(CAC)的独立危险因素,进一步分析血清骨桥蛋白(OPN)与CAC及其危险因素的相关性。方法:据64层螺旋CT冠脉造影结果连续入选65例患者,分为冠脉钙化(CAC)组(37例)和非冠脉钙化(UCAC)对照组(28例),用酶联免疫吸附法(ELISA)测定血清OPN水平。分别进行单因素和多因素Logis-tic回归分析研究冠脉钙化的危险因素,血清OPN与CAC危险因素的相关性采用Spearman′s相关分析。结果:1、将单因素Logistic回归分析有统计学意义的年龄、高血压,糖尿病,饮食习惯不佳,缺乏运动,超重(OR=3.47～12.96,P=0.018～0.003)等变量引入多因素Logistic回归分析,结果多因素Logistic回归分析显示年龄、超重、睡眠质量差、饮食习惯不佳是CAC的独立危险因素,OR为35.31～5.17,P<0.01～<0.05;2、CAC组血清OPN水平显著高于UCAC组[(39.919±11.879)μg/L比(24.000±6.000)μg/L,P<0.01];3、Spearman′s直线相关分析显示血清OPN水平与CAC危险因素:LDL-C、超重、年龄、TC呈正相关(r=0.487～0.286,P<0.001～<0.05),与睡眠质量差、糖尿病、不良饮食习惯、缺乏运动呈正相关(r=4.10～2.24,P<0.01～<0.05);与HDL-C呈负相关(r=-0.250,P<0.05)。结论:相关分析显示年龄、超重、睡眠质量差、不良饮食习惯等是CAC独立危险因素;血清OPN水平与LDL-C、超重、年龄、糖尿病、缺乏运动等相关。这说明应降低OPN水平,减少CAC危险因素,以减轻冠脉钙化、减慢其发展。
Objective: To investigate the independent risk factors of coronary artery calcification (CAC) and to further analyze the correlation between serum osteopontin (OPN) and CAC and its risk factors. Methods: Sixty-five consecutive patients with coronary artery calcification (CAC) (37 cases) and non-coronary artery calcification (UCAC) control group (28 cases) were enrolled in this study based on 64-slice spiral CT coronary angiography. The level of serum OPN was measured by ELISA. Univariate and multivariate Logis-tic regression analysis were used to analyze the risk factors of coronary artery calcification. The correlation between serum OPN and CAC risk factors was analyzed by Spearman’s correlation. Logistic regression analysis showed that multivariate Logistic regression analysis was used to analyze the relationship between age, hypertension, diabetes, poor eating habits, lack of exercise and overweight (OR = 3.47-12.96, P = 0.018-0.003) Logistic regression analysis showed that age, overweight, poor quality of sleep and poor eating habits were independent risk factors for CAC, OR was 35.31 ~ 5.17, P <0.01 ~ <0.05; 2, serum OPN levels in CAC group were significantly (39.919 ± 11.879) μg / L (24.000 ± 6.000) μg / L, P <0.01]; 3, Spearman’s linear correlation analysis showed that serum OPN levels and CAC risk factors: LDL-C, overweight , Age and TC (r = 0.487-0.286, P <0.001-0.05), and was positively correlated with poor sleep quality, diabetes, poor diet and lack of exercise (r = 4.10-2.24, P <0.01-0.05) ; Negatively correlated with HDL-C (r = -0.250, P <0.05). Conclusion: Correlation analysis showed that age, overweight, poor sleep quality and poor eating habits were independent risk factors for CAC. Serum OPN levels were associated with LDL-C, overweight, age, diabetes and lack of exercise. This shows that should reduce the level of OPN, CAC risk factors to reduce, in order to reduce coronary calcium, slowed its development.