目的:探讨维吾尔族男性冠心病患者血清C-反应蛋白(CRP)、白介素-6(IL-6)和血浆纤维蛋白原(FBG)的变化及相互关系。方法:选取45例冠心病患者(冠心病组)及30例健康体检者(正常对照组),采血检测CRP、FBGI、L-6水平,并进行对照分析。结果:冠心病组CRP为(5.86±3.28)mg/L,FBG为(4.17±1.35)g/L,IL-6为(151.08±26.72)ng/L,均较对照组明显增高(P均<0.01)。对照组CRP、FBGI、L-6均无相关性(P>0.05);冠心病组IL-6与CRP及FBG均呈正相关(P均<0.01,r分别为0.67、0.65、0.86)。结论:血清IL-6、CRP及血浆FBG增高是冠心病独立危险因素,均与冠心病的发生、发展有密切关系,3项指标有很好的相关性。 Objective: To investigate the changes and correlations of serum C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen (FBG) in Uygur male patients with coronary heart disease. Methods: 45 Coronary heart disease patients (CHD group) and 30 healthy subjects (control group) were selected. Blood samples were collected for the determination of CRP, FBGI and L-6 levels. Results: The CRP in coronary heart disease group was (5.86 ± 3.28) mg / L, FBG was (4.17 ± 1.35) g / L and IL-6 was (151.08 ± 26.72) ng / L, 0.01). There was no correlation between CRP, FBGI and L-6 in control group (P> 0.05). There was a positive correlation between IL-6 and CRP and FBG in CHD patients (all P <0.01, r = 0.67,0.65 and 0.86 respectively). CONCLUSIONS: Elevated serum levels of IL-6, CRP and elevated plasma FBG are independent risk factors for coronary heart disease, both of which are closely related to the occurrence and development of coronary heart disease. There are good correlations among the three indicators.