结缔组织疾病(CTDs)是一组涉及关节、皮肤和内脏器官等多系统疾病。虽然多数CTDs 病因不明,但绝大多数被认为与自身免疫发病机理有关,CTDs 的诊断依赖于仔细的临床检查和对复杂症状的分析,在CTD病人血清中常可检出抗核酸和蛋白抗体,这些自身抗体的测定为CTDs 的诊断提供了有益的佐证。由于最近发现一些其它自身抗体,因此,一些新的CTD 综合症已被认识,在某些情况下,对原先提出的综合症需要重新加以确定。 Connective tissue diseases (CTDs) are a group of multisystem diseases involving joints, skin and internal organs. Although the etiology of most CTDs is unknown, the vast majority are thought to be involved in the pathogenesis of autoimmunity. The diagnosis of CTDs depends on careful clinical examination and analysis of complex symptoms. Anti-nucleic acid and protein antibodies are often detectable in the serum of CTD patients, and these The determination of autoantibodies provides useful evidence for the diagnosis of CTDs. As some other autoantibodies have recently been identified, a number of new CTD syndromes have been identified and in some cases the previously proposed syndrome needs to be re-identified.