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目的探讨新生儿先天性巨细胞病毒(CMV)感染患儿血清β2微球蛋白(β2-MG)检测的意义。方法采用微粒子免疫定量分析法对确诊的新生儿先天性CMV感染患儿(观察组)及同期住院的其他新生儿(对照组)测定血清β2-MG,并进行比较,观察组与对照组病例数比例为1∶2;建立血清β2-MG诊断CMV感染的工作曲线,确定ROC曲线下的面积,同时分析不同截断值的敏感度和特异度。结果观察组共21例,血清β2-MG值为(3112±910)μg/L,对照组共42例,为(2470±624)μg/L,差异有统计学意义(P<0.01);取观察组血清β2-MG3000μg/L为截断值,其敏感度为52.38%,特异度为82.71%。结论血清β2-MG可作为先天性CMV感染诊断的辅助指标,便捷实用,适于基层医院临床开展。
Objective To investigate the significance of serum β2-microglobulin (β2-MG) in neonates with congenital cytomegalovirus (CMV) infection. Methods Serum β2-MG was measured in children with congenital CMV infection and other newborns in the same period (control group) by using the method of microparticle immunoassay. The number of cases in the observation group and the control group The proportion of 1: 2; serum β2-MG diagnosis of CMV infection working curve to determine the area under the ROC curve, while analyzing the sensitivity and specificity of different cut-off values. Results There were 21 cases in the observation group, the serum β2-MG value was (3112 ± 910) μg / L in the control group and 42 cases in the control group (2470 ± 624 μg / L), with statistical significance (P <0.01) The observation group serum β2-MG3000μg / L cut-off value, the sensitivity was 52.38%, the specificity was 82.71%. Conclusion Serum β2-MG can be used as an auxiliary index in the diagnosis of congenital CMV infection, which is convenient and practical and suitable for the clinical implementation of primary hospital.