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目的 探讨糖耐量受损 (IGT)患者胰岛素抵抗、β细胞功能和相关的代谢改变。 方法 对 6 4例血糖正常者 (NGT)和 97例IGT患者进行口服葡萄糖耐量试验 (OGTT)、胰岛素释放试验 ,并测定其血脂、血压、体重指数 (BMI)和腰臀比值 (WHR)。结果 与NGT组比较 ,IGT组空腹胰岛素水平、OGTT后胰岛素曲线下面积显著升高 (P <0 0 5 ) ;胰岛素敏感指数、初期胰岛素分泌指数明显降低 (P <0 0 1) ;胰岛素敏感指数依次与腰臀比值、BMI、甘油三脂 (TG)、高密度脂蛋白 胆固醇 (HDL C)、空腹血糖和舒张压相关 ;IGT患者TG、舒张压、收缩压、BMI和腰臀比值明显增高 ,HDL C明显降低。结论 IGT患者存在胰岛素抵抗和 β细胞功能异常并伴有多种代谢紊乱。
Objective To investigate the changes of insulin resistance, β-cell function and related metabolism in patients with impaired glucose tolerance (IGT). Methods Oral glucose tolerance test (OGTT) and insulin release test were performed on 64 normal blood glucose (NGT) patients and 97 IGT patients. Blood lipids, blood pressure, body mass index (BMI) and waist - hip ratio (WHR) were measured. Results Compared with NGT group, the fasting insulin level and the area under the curve of insulin concentration after OGTT in IGT group were significantly increased (P <0.05); insulin sensitivity index and initial insulin secretion index were significantly decreased (P <0.01); insulin sensitivity index The ratio of waist to hip, BMI, TG, HDL C, fasting blood glucose and diastolic blood pressure were correlated with each other. TG, diastolic blood pressure, systolic blood pressure, BMI and waist-hip ratio were significantly increased in patients with IGT, HDL C decreased significantly. Conclusion IGT patients have insulin resistance and β-cell dysfunction with a variety of metabolic disorders.