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目的： 观察 Ｎｏｒｐｌａｎｔ 致子宫不规则出血时内膜血管的变化， 探讨二者的关系。方法：用组织学和免疫组织化学方法对使用 Ｎｏｒｐｌａｎｔ 后 （０５ 、１ ａ 及＞ ２ ａ） 月经规律及有子宫不规则出血者的子宫内膜进行形态学、内膜血管内皮细胞 Ｃ Ｄ３４ 和基膜层粘连蛋白 （ Ｌ Ｎ） 观察。结果： Ｎｏｒｐｌａｎｔ 使用者子宫内膜均无典型的周期特点， 血管内皮变薄； 出血不规则的内膜血管基膜 Ｌ Ｎ 明显减少。结论： Ｎｏｒｐｌａｎｔ 使用者子宫出血不规则与内膜血管内皮变薄和基膜 Ｌ Ｎ减少有密切关系。
Objective: To observe the changes of endometrial vessels during Norplant-induced uterine irregular hemorrhage and to explore the relationship between the two. Methods: The histological and immunohistochemical methods were used to study the morphological and endometrial vascular endothelium C D34 in the endometrium of menopausal women with irregular menstruation and irregular uterine bleeding after Norplant (05, 1 a and> 2 a) And basal laminin (L N) observation. Results: The endometrium of Norplant users had no typical cycle characteristics and the endothelium became thinner. L N in the irregular basement membrane of hemorrhage was significantly decreased. Conclusion: Irregular uterine bleeding in Norplant users is closely related to the thinning of endothelium and the decrease of L N in basement membrane.