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目的:探讨肿瘤坏死因子α(TNF-α)在急性脑梗死中的作用机制。方法:比较84例急性脑梗死患者与80例健康对照组之间TNF-α、血脂、尿酸(UA)、纤维蛋白原(FIB)、体重指数(BMI)有无差异。结果:急性脑梗死组中TNF-α、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、UA、FIB明显高于对照组,P<0.01或P<0.05。结论:急性脑梗死是多种因素、多种机制共同作用的结果,TNF-α可作用于多种细胞,通过多种途径加重缺血后脑损伤。
Objective: To investigate the mechanism of tumor necrosis factor α (TNF-α) in acute cerebral infarction. Methods: The differences of TNF-α, serum lipids, uric acid (UA), fibrinogen (FIB) and body mass index (BMI) between 84 patients with acute cerebral infarction and 80 healthy controls were compared. Results: TNF-α, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), UA and FIB in acute cerebral infarction group were significantly higher than those in control group, P <0.01 or P <0.05. Conclusion: Acute cerebral infarction is the result of many factors and various mechanisms. TNF-α can act on many kinds of cells and increase the ischemic brain injury through a variety of ways.