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目的：探讨5-氨基酸酮戊光动力学疗法（ALA-PDL）在预防尿道尖锐湿疣术术后复发中的意义。方法将我院收治的100例确诊为尿道尖锐湿疣患者按照入院时间随机分为对照组（单独电灼治疗）和治疗组（ALA-PDL联合电灼治疗），对比观察两组患者的复发率以及不良反应。结果治疗组的复发率（9. 3%）明显低于对照组（36%），治疗组的不良反应发生率（8%）明显低于对照组（56%），差异对比均具有统计学意义（P<0. 05）。结论ALA-PDL联合电灼治疗尿道CA的疗效显著，术后复发率较低，不良反应较少，是一种安全、有效的治疗方法。“,”Objective:To study meaning of photodynamic therapy of 5-ketone amino acids in prevention of postoperative recurrence of urethra condyloma acuminatum operation. Methods:100 patients diagnosed as urethral condyloma acuminatum in our hospital were randomly divided into control group (electric bright treatment alone) and treatment group (ALA-PDL with electric bright therapy), according to admission time. Recurrence rate and adverse reaction of patients of two groups were comparated and observed.Results:Recurrence rate (9.3%) of treatment group was obviously lower than the control group (36%), and the incidence of adverse reactions (8%) of treatment group was obviously lower than the control group (56%).Contrast differences were statistical y significant (P < 0.05). Conclusion:Curative effect of ALA-PDL combined with fulguration for the treatment of urethral CA is distinct, and its postoperative recurrence rate is low. It has less adverse reaction, and is a safe and effective treatment method.