TRH广泛分布于哺乳类动物中枢神经系统中,不仅刺激甲状腺素及催乳素分泌,对中枢神经系统也有作用。TRH除能拮抗乙醛或巴比妥酸盐产生的低温,还有增强动物运动的作用。据推测,TRH可不依赖垂体—甲状腺轴而对动物行为发生影响。关于人体脑脊液(CSF)中TRH水平的报道很少,本文作者报告用放免法检测不同神经性疾患的人体CSF中TRH水平。 TRH is widely distributed in the mammalian central nervous system, not only stimulating the secretion of thyroxine and prolactin, but also on the central nervous system. In addition to being able to antagonize the hypothermia produced by acetaldehyde or barbiturate, TRH also enhances animal motility. It is speculated that TRH can affect animal behavior independently of the pituitary-thyroid axis. There have been few reports of TRH levels in human cerebrospinal fluid (CSF), and the authors report the use of radioimmunoassay to detect TRH levels in human CSF with different neurological disorders.