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呼吸道合胞病毒(RSV)是小于6月龄婴儿严重下呼吸道疾病的主要病因。该年龄组的婴儿,可通过胎盘或母乳喂养而获得保护力。母乳中已检测到RSV特异的SIgA与中和活性。然而母乳喂养婴儿在RSV感染后能抑制病毒特异的淋巴细胞转化(LTF)活性,提示母乳喂养可能存在着调节RSV感染婴儿免疫应答的独特机理。作者对RSV感染患儿体内的干扰素(IFN)反应及其RSV特异的LTF活性进行了检测,以分析母乳喂养对这些反应是否有影响。
Respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract disease in infants less than 6 months of age. Infants in this age group are protected by placenta or breastfeeding. RSV-specific SIgA and neutralizing activity have been detected in breast milk. However, breastfeeding infants suppressed viral-specific lymphocyte transformation (LTF) activity after RSV infection, suggesting that breastfeeding may have a unique mechanism for modulating the immune response in infants infected with RSV. The authors tested interferon (IFN) responses in infants with RSV infection and their RSV-specific LTF activity to determine if breastfeeding had any effect on these responses.