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作者用埃及伊蚊作为实验室模型,评估伊维菌素对蚊虫繁殖方面的影响。使用家兔(1年龄,4～5kg)皮下注射伊维菌素剂量分2mg/kg(一处)注射和10mg/kg(二处注射)两组,并设置对照动物,分笼饲养于25℃空调房内。给药3d后待药物血浓度达高峰时给蚊虫进行第一次血餐。隔周进行生物测定,将实验动物暴露于蚊笼中1.5h,从给药组和对照组的饱血蚊中各选取25只,置小管中单只饲养,并观察其存活和产卵,并将其所产卵放入水中孵化,24h后检查卵孵化情况,3～4d后统计3～4龄幼虫数。统计处理低剂量组使用t检验;高剂量组则用SAS非线性回
The authors used the Aedes aegypti as a laboratory model to assess the effects of ivermectin on mosquito breeding. Rabbits (1 year old, 4 ~ 5kg) were injected subcutaneously with 2mg / kg ivermectin (one injection) and 10mg / kg (two injection) rabbits respectively. Control animals were housed at 25 ℃ Air-conditioned room. 3d after administration of drug blood concentration reached the peak when the first blood meal to the mosquito. Bioassays were performed every other week, and the experimental animals were exposed to mosquitoes for 1.5h. Twenty-five blood-sucking mosquitoes from the drug-treated group and the control group were selected and housed in a single tube and observed for survival and spawning. The eggs were hatched in water, egg hatching was checked after 24 hours, 3 ~ 4 days after the statistics of 3 to 4 larvae. Statistical analysis of low-dose group using t test; high-dose group SAS non-linear back