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为了探讨血清层粘蛋白(LN)在慢性肝病诊断中的意义,本文应用酶标法检测了72例慢性肝病、15例非肝病患者及20例正常对照组的血清LN含量。结果发现肝硬化、慢性活动性肝炎、慢性迁延性肝炎患者血清LN含量显著高于正常对照组及其他非肝病组,同时发现血清LN与肝功能ChildPugh分级呈正相关(r=0.385,P<0.01)、与血清白蛋白呈负相关(r=-0.297,P<0.05),与食管静脉曲张程度呈正相关(r=0.635,P<0.05)。提示:血清LN对肝纤维化及早期肝硬化的诊断有重要价值,可作为估计肝硬化程度及判断门静脉高压的非创伤性血清学指标。但缺乏高特异性,宜与其他指标联合应用以提高特异性。
In order to investigate the significance of serum laminin (LN) in the diagnosis of chronic liver disease, the serum level of LN in 72 patients with chronic liver disease, 15 patients with non-liver disease and 20 healthy controls was detected by enzyme-linked immunosorbent assay. The results showed that the levels of serum LN in patients with cirrhosis, chronic active hepatitis and chronic persistent hepatitis were significantly higher than those in normal controls and other non-liver disease groups. Also, serum LN was positively correlated with Child Pugh classification of liver function (r = 0.385, P <0.01) , Negatively correlated with serum albumin (r = -0.297, P <0.05), and positively correlated with the degree of esophageal varices (r = 0.635, P <0.05). Tip: Serum LN has important value in the diagnosis of liver fibrosis and early cirrhosis. It can be used as a non-invasive serological indicator to evaluate the degree of cirrhosis and to determine portal hypertension. However, the lack of high specificity, should be combined with other indicators to improve specificity.