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目的检测慢性牙周炎患者在牙周基础治疗前后龈沟液(CGF)中血管内皮生长因子(VEGF)的含量,研究VEGF在牙周炎的病情进展及治疗监测过程中的意义。方法采用滤纸条法采集健康者以及慢性牙周炎患者的龈沟液,用酶联免疫法检测治疗前及治疗中VEGF的含量。结果慢性牙周炎患者的龈沟液中VEGF的含量高于健康组(P<0.01)。治疗的第4,8,12周VEGF含量低于治疗前(P<0.01)。龈沟液中VEGF的含量与牙周探诊深度(PD)有相关。结论 VEGF可以作为在牙周炎的病情进展及治疗监测过程中的指标之一。
Objective To detect the content of vascular endothelial growth factor (VEGF) in gingival crevicular fluid (CGF) in patients with chronic periodontitis before and after periodontal treatment and to investigate the significance of VEGF in the progression of the periodontitis and the monitoring of the treatment. Methods The gingival crevicular fluid of healthy volunteers and patients with chronic periodontitis was collected by filter paper method. The content of VEGF before and during treatment was detected by enzyme-linked immunosorbent assay. Results The content of VEGF in gingival crevicular fluid of patients with chronic periodontitis was higher than that of healthy controls (P <0.01). VEGF levels at 4, 8 and 12 weeks after treatment were lower than those before treatment (P <0.01). Gingival crevicular fluid VEGF content and periodontal exploration depth (PD) are related. Conclusion VEGF can be used as one of the indicators in the progress of periodontitis and monitoring of treatment.