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【目的】观察两种不同剂量乙肝疫苗接种对阻断母婴传播的效果。【方法】根据上海市卫生局文件实施日期为分组界限,对2007年3月后HBsAg单阳性和HBeAg双阳性孕妇所产患儿注射乙肝疫苗10μg,同时注射乙肝免疫球蛋白100 U(设为10μg联合疫苗组)(3月前为注射5μg疫苗,设为5μg单用疫苗组)。均按0-1-6方案接种。观察不同剂量疫苗组在脐带血及出生后3、7、12月HBsAg、HbsAb阳性率。【结果】5μg单用疫苗组HBsAg阳性率在脐带血及出生后3、7月和12月与10μg联合疫苗组相比差异无显著性(P>0.05);HbsAb阳性率在脐带血时差异无显著性(P>0.05),在3、7、12月时差异有显著性(P<0.05)。【结论】接种重组酵母乙肝疫苗剂量为10μg,同时不同部位注射免疫球蛋白100 U比接种5μg疫苗获得更好的保护性效果,对HBsAg阳性率无明显影响。
【Objective】 To observe the effect of two different doses of hepatitis B vaccine on the prevention of mother-to-child transmission. 【Method】 According to the document of Shanghai Municipal Health Bureau, the date of implementation of the document was divided into groups, and 10 μg of hepatitis B vaccine and 100 μg of hepatitis B immunoglobulin were injected into children born in HBsAg single positive and HBeAg double positive pregnant women after March 2007, Combined vaccine group) (5 μg vaccine injected 3 months ago, 5 μg single vaccine group). According to 0-1-6 program inoculation. The positive rates of HBsAg and HbsAb in cord blood and postnatal 3, 7 and 12 months after different doses of vaccine were observed. 【Results】 The positive rate of HBsAg in 5μg single vaccine group was no significant difference between umbilical cord blood and 3, 7 and 12 months after birth as compared with 10μg vaccine (P> 0.05). The positive rate of HbsAb in umbilical cord blood was no difference (P> 0.05). There was a significant difference between March, July and December (P <0.05). 【Conclusion】 The inoculated recombinant hepatitis B vaccine dose of 10μg, at the same time different parts of the injection of immunoglobulin 100 U than inoculation 5μg vaccine to obtain better protective effect, HBsAg positive rate had no significant effect.