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目的探讨妊娠早期孕妇血清解整合素-金属蛋白质酶12(ADAM12-S)水平变化与唐氏综合征等妊娠结局的关系。方法应用时间分辨荧光免疫分析法检测早孕期(8-11周)孕妇血清中ADAM12-S水平,并分析ADAM12-S水平变化与唐氏综合征等妊娠结局的关系。结果正常单胎血清ADAM12-S水平随孕周增加而逐渐上升的趋势,且呈线性相关(r=0.993,P<0.01)。唐氏综合征等非整倍体染色体异常的ADAM12-S水平的明显低于正常单胎孕妇,差异有统计学意义(P<0.05).结论早孕期孕妇血清中ADAM12-S水平随孕周增加而上升,可用于非整倍体常染色体异常的筛查,预测胎停育、异位妊娠等早期妊娠丢失,可作为产前筛查指标。
Objective To investigate the relationship between serum levels of integrin-metalloproteinase-12 (ADAM12-S) and pregnancy outcome in Down’s syndrome in the first trimester of pregnancy. Methods The serum level of ADAM12-S in pregnant women during the first trimester (8-11 weeks) was detected by time-resolved fluorescence immunoassay. The relationship between ADAM12-S levels and pregnancy outcomes such as Down’s syndrome was analyzed. Results The level of ADAM12-S in normal single fetus serum increased gradually with the increase of gestational age, and was linearly correlated (r = 0.993, P <0.01). The level of ADAM12-S in aneuploidy such as Down Syndrome was significantly lower than that in normal singleton pregnant women (P <0.05) .Conclusion The level of ADAM12-S in pregnant women with early pregnancy increased with gestational age Which can be used for screening of aneuploidy autosomal abnormalities, predicting the loss of early pregnancy such as fetal suspension and ectopic pregnancy, which can be used as an index of prenatal screening.