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心血管疾病的性别差异使得人们开始重新审视甾体类激素的作用。雌激素和(或)孕激素对于心血管的保护作用近年来不断受到质疑,于是研究热点逐渐转移到雄激素。近年来的分子生物学研究已经证实雄激素受体(androgen recep-tor,AR)广泛存在于哺乳动物的心血管系统内。雄激素只在AR存在的靶组织细胞中才能发挥其生物学功能。因此,要从分子水平认识心血管疾病的性别差异,AR是关键环节。
Sexual differences in cardiovascular disease have led people to start re-examining the role of steroid hormones. The protective effect of estrogen and / or progestin on cardiovascular system has been constantly questioned in recent years, so the research focus gradually transferred to androgen. In recent years, molecular biology studies have confirmed that androgen recep-tor (AR) is widely found in mammalian cardiovascular system. Androgen exerts its biological function only in the target tissue cells present in the AR. Therefore, to understand the gender differences in cardiovascular disease at the molecular level, AR is the key link.