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目的:研究女性更年期高血压患者脉压变化与颈动脉粥样硬化斑块形成的关系。方法:选择1、2、3级女性更年期高血压患者各30例为研究对象,并以30例健康体检者作为对照,对所有入选者行动态血压监测,做颈动脉血管超声测量颈总动脉内膜-中层厚度、颈总动脉内径,局限性内膜-中层厚度增厚≥1.3mm定义为斑块。结果:1、2、3级女性更年期高血压组与对照组颈动脉IMT及ID比较有统计学意义(P<0.05),且随着脉压增高,颈动脉粥样硬化斑块程度加重。结论:脉压增大及血压昼夜节律异常是颈动脉粥样硬化斑块形成的危险因素。
Objective: To study the relationship between pulse pressure changes and carotid atherosclerosis plaque formation in female patients with menopause. Methods: Thirty cases of female climacteric hypertensive patients were selected as study objects. 30 healthy subjects were used as control. All patients were monitored for ambulatory blood pressure, carotid artery ultrasound was used to measure the common carotid artery Membrane - middle thickness, carotid artery diameter, limitations Intimal - middle thickness thickening ≥ 1.3mm is defined as plaques. Results: The IMT and ID of carotid artery in menopausal women with menopausal stage 1, 2, and 3 were statistically significant (P <0.05). The carotid atherosclerotic plaque was aggravated with the increase of pulse pressure. Conclusion: Increased pulse pressure and abnormal circadian rhythm of blood pressure are the risk factors for the formation of carotid atherosclerosis plaque.