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案例报道男,56岁,心功能正常,患恶性黑色素瘤,采用干扰素-α-2b治疗。用药8个月后,出现易疲劳、用力时呼吸困难等状况。2个月后,因端坐呼吸、呼吸困难和咳嗽加重入院。体检结果显示为充血性心力衰竭。实验室检查显示甲状腺功能明显减退。超声心动图结果显示左室大部分有严重的功能障碍。检查项目:超声心动图、心电图、血常规、冠脉造影、右心及左心插管和心内膜心肌活检。诊断:干扰素-α-2b诱发心肌病。处理:停用干扰素-α-2b,发生心源性休克时静注多巴酚丁胺和多巴胺抢救。
Case Report Male, 56 years old with normal cardiac function and malignant melanoma treated with interferon-α-2b. After 8 months of medication, there is easy to fatigue, hard breathing and other conditions. Two months later, due to sitting, breathing difficulties and cough increased admission. Physical examination results showed congestive heart failure. Laboratory tests showed a marked decrease in thyroid function. Echocardiographic findings showed that most of the left ventricle had severe dysfunction. Check items: echocardiography, electrocardiogram, blood, coronary angiography, right and left cardiac catheterization and endomyocardial biopsy. Diagnosis: Interferon-alpha-2b induces cardiomyopathy. Treatment: Disable interferon-α-2b, intravenous dobutamine and dopamine rescue in the event of cardiogenic shock.