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目的 检测晚期非小细胞肺癌患者化疗前后血清肿瘤标志物水平的改变.方法 52例接受化疗的晚期非小细胞肺癌患者列为观察组.另纳入同期健康体检者45例作为对照组.检测观察组治疗前后及对照组外周血前梯度同源蛋白2(AGR2)、可溶性白细胞介素-2受体(SIL-2R)及血清胸苷激酶1(TK1)水平.结果 观察组患者疗效为完全缓解(1级)0例,部分缓解(2级)16例,稳定(3级)19例及进展(4级)17例.化疗后,观察组患者外周血AGR2、SIL-2R及TK1水平均较化疗前显著降低(P<0.05).观察组患者化疗2周期后外周血AGR2、SIL-2R及TK1水平与化疗效果等级均呈现显著正相关(P<0.05).结论 血清AGR2、SIL-2R及血清TK1在晚期非小细胞肺癌化疗后显著降低,且下降水平与化疗效果相关.“,”Objective To detect the changes of serum tumor markers before and after chemotherapy in patients with advanced non-small cell lung cancer.Methods Fifty-two patients with advanced non-small cell lung cancer by chemotherapy were selected as observation group,and forty-five healthy controls were selected as control group.Peripheral blood anterior gradient precursor protein 2(AGR2),soluble interleukin-2 receptor(SIL-2R)and serum thymidine kinase 1(TK1)levels were detected before and after treatment in both groups.Results The curative effects of the observation group were 0 case of complete remission(grade 1),16 cases of partial remission(grade 2),19 cases of stability(grade 3)and 17 cases of progression(grade 4).After treatment,the levels of AGR2,SIL-2Rand TK1 decreased significantly in observation group(P<0.05).Correlation analysis showed that after two cycles of treatment,the levels of AGR2,SIL-2R and TK1 were positively correlated with the therapeutic effect grade(P<0.05).Conclusion AGR2,SIL-2R and TK1 reduce significantly after chemotherapy in patients with advanced non-small cell lung cancer,and its decreasing level is correlated with chemotherapy effect.