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目的探讨多原发癌(multiple primary cancers,MPC)的病因,临床特征,治疗和预后,以期提高对多原发癌的诊治水平。方法对我院2003年1月—2011年12月收治的26例MPC患者的临床资料进行回顾性分析。结果研究期间的2 589例恶性肿瘤患者中发现MPC26例,其总的发病率1.0%(26/2589),其中双重癌24例,三重癌2例。发病间隔时间<3年8例,3～5年9例;最长间隔时间为18年。首发癌和重复癌均以消化系统肿瘤最常见,其次是肺癌、乳腺癌、泌尿生殖系统肿瘤。经外科手术或放、化疗等综合治疗后的3年生存率为53.8%,5年生存率为30.7%。结论临床工作中应足够重视多原发癌,避免误诊和漏诊,尽可能早期发现、早期诊治,获得较好疗效。
Objective To investigate the etiology, clinical features, treatment and prognosis of multiple primary cancers (MPC) in order to improve the diagnosis and treatment of multiple primary cancers. Methods The clinical data of 26 MPC patients admitted to our hospital from January 2003 to December 2011 were analyzed retrospectively. Results Twenty-six MPC cases were found in 2 589 cases of malignant tumors during the study period, with a total incidence of 1.0% (26/2589), including 24 cases of double carcinomas and 2 cases of triple cancers. Incidence of time <3 years in 8 cases, 3 to 5 years in 9 cases; the longest interval of 18 years. The first and second cancers are the most common digestive system tumors, followed by lung cancer, breast cancer, genitourinary tumors. After surgery or radiotherapy, chemotherapy and other comprehensive treatment of 3-year survival rate was 53.8%, 5-year survival rate was 30.7%. Conclusion Clinical work should pay enough attention to multiple primary cancer, to avoid misdiagnosis and missed diagnosis, as early as possible to find, early diagnosis and treatment, access to better efficacy.