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肝纤维化(hepatic fibrosis)是指肝细胞发生坏死及炎症刺激时,肝内纤维结缔组织异常增生的病理过程。它是一个极其复杂的动态过程,它的形成是多种细胞、多种因子相互促进、相互制约的结果。目前临床上对肝纤维化的诊断仍以肝活检为主,但它具有创伤性,难以动态观察,所以肝纤维化血清学诊断价值日益受到人们重视。理想的血清学标志物应反映纤维生成与降解的动态过程,反映肝纤维化程度,即细胞外基质的量。近年来,许多血清学标志物已应用于临床,还有许多正在研究中。本文就近年的内容作一简介。 1 反映胶原蛋白代谢的指标在肝脏内胶原蛋白占蛋白总量的5%～10%。肝纤维化时,间质内主要是胶原成分发生异常沉积,其
Hepatic fibrosis (hepatic fibrosis) refers to the liver cell necrosis and inflammatory stimuli, the intrahepatic fibrous connective tissue abnormal proliferation of the pathological process. It is an extremely complex and dynamic process. Its formation is the result of a variety of cells and various factors mutually reinforcing and restricting each other. At present, the clinical diagnosis of liver fibrosis is still based on liver biopsy, but it is traumatic and difficult to observe dynamically. Therefore, the value of serological diagnosis of liver fibrosis has been paid more and more attention. Ideal serological markers should reflect the dynamic process of fiber formation and degradation, reflecting the degree of liver fibrosis, that is, the amount of extracellular matrix. In recent years, many serological markers have been used clinically, and many are under study. This article makes an introduction to the content in recent years. 1 reflect the indicators of collagen metabolism in the liver collagen protein accounted for 5% to 10% of the total. Liver fibrosis, the interstitial collagen components are mainly abnormal deposition