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目的探讨三模块治疗高龄肌层浸润性膀胱癌的临床疗效。方法对医院收治的高龄肌层浸润性膀胱癌,并进行了保留膀胱三模块治疗的53例患者临床资料进行回顾性分析,探讨三模块治疗高龄肌层浸润性膀胱癌的临床疗效。结果本组53例中,有26例(49.1%)在治疗过程中,未出现排尿困难、肠炎等并发症,能完成三模块整个治疗过程。有36例随访3年,其中21例(58.3%)无复发及转移,12例(33.3%)再次行三模块治疗,3例(8.3%)因脏器功能衰竭死亡;17例随访5年,4例(23.5%)无复发和转移,7例(41.1%)再次行三模块治疗,6例(35.3%)因脏器功能衰竭死亡。结论保留膀胱的三模块治疗高龄浸润性膀胱癌,可避免根治行膀胱切除术的众多并发症,有利于提高患者生活质量,同时可有效控制肿瘤的进展,是一种可供选择的合理治疗方案。
Objective To investigate the clinical efficacy of three modules in the treatment of advanced muscle invasive bladder cancer. Methods A retrospective analysis was performed on the clinical data of 53 patients with advanced myometrial invasive bladder cancer who had been treated in our hospital. The clinical data of 53 patients who had retained bladder three-module therapy were retrospectively analyzed to explore the clinical efficacy of the three-module therapy in the treatment of advanced muscle invasive bladder cancer. Results Of the 53 cases, 26 cases (49.1%) did not have complications such as dysuria and enteritis during the course of treatment, and could complete the whole treatment process of the three modules. Thirty-six patients were followed up for 3 years, 21 of them (58.3%) had no recurrence and metastasis, 12 patients (33.3%) were treated by three modules again, 3 patients (8.3%) died of organ failure, 17 patients were followed up for 5 years, No recurrence and metastasis occurred in 4 cases (23.5%). Three cases were treated again in 7 cases (41.1%), and 6 cases (35.3%) died of organ failure. Conclusion The three-module bladder preserving treatment of advanced invasive bladder cancer can avoid many complications of radical cystectomy, improve the quality of life of patients and effectively control the progress of the tumor, and is an alternative and reasonable treatment plan .