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肿瘤化疗失败主要原因之一是肿瘤细胞本身对药物产生耐药性，多药耐药性（ＭｕｌｔｉｄｒｕｇＲｅｓｉｓｔａｎｃｅ，ＭＤＲ）又是耐药类型中十分重要的一种类别。ＭＤＲ是指肿瘤细胞接触了一种药物后，不但对该药物产生耐药性，而且对其它结构和作用机制不同的药物也产生耐药
One of the main reasons for failure of cancer chemotherapy is that tumor cells themselves are resistant to drugs, and Multidrug Resistance (MDR) is a very important category of drug resistance. MDR means that after a tumor cell is exposed to a drug, it is not only resistant to the drug, but also resistant to other drugs with different structures and mechanisms of action.