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红花系菊科,性温味辛,有活血通经、祛瘀止痛功效。近年来实验研究表明,红花具有扩张血管,增加血流量改善微循环的作用,对小鼠减压缺氧耐力有延长存活作用,对脑减压缺氧及缺血幼鼠脑神经元具有明显的保护作用。本实验旨以大鼠心肌为模型,探讨红花对心肌缺氧、复氧损伤的影响,为临床应用红花黄素治疗冠心病提供理论依据。1 材料和方法 250g重的大鼠,击头致昏后取心,制备乳头肌标本,置于容积1.5ml的灌注槽中,用95％O_2+5％CO_2饱合的台氏液循环灌流乳头肌标本,灌流液PH7.4,37±0.5℃,用微电极操纵器将微电极插入心肌细胞内,记录到的膜电位输入计算机进行分析,整个过
The Department of Asteraceae in the safflower family is warm and spicy. It has the effect of promoting blood circulation and relieving pain. In recent years, experimental studies have shown that safflower has the function of dilating blood vessels, increasing blood flow and improving microcirculation, prolonging the survival of decompression and hypoxia tolerance in mice, and has obvious effects on cerebral hypoxia and cerebral neurons of ischemic young rats. Protection. The purpose of this experiment is to use rat heart muscle as a model to investigate the effect of safflower on myocardial hypoxia and reoxygenation injury, and provide theoretical basis for the clinical application of safflor yellow in the treatment of coronary heart disease. 1Materials and Methods Rats weighing 250 g were collected from the head of the head to prepare a papillary muscle specimen. The specimen was placed in a 1.5 ml perfusion tank, and the nipple was circulated and perfused with 95% O 2 + 5% CO 2 saturated Tyrode’s solution. Muscle specimens, perfusate pH7.4, 37±0.5°C, microelectrode was used to insert microelectrodes into cardiomyocytes, and the recorded membrane potential was input into computer for analysis.