论文部分内容阅读
盐酸贝利地尔(Bepridil)虽属钙通道阻滞剂,但其化学结构与维拉帕米,硝苯啶类药物不相关。近来,FDA准予口服治疗慢性稳定型心绞痛。由于本药具有一些潜在的副作用,建议仅在对其他抗心绞痛药物不能耐受或效果不良时才使用。药理贝利地尔与以往使用的钙通道阻滞剂不同,可阻滞慢钙和快钠通道,并同时阻滞电压依赖的和受体起动的钙通道。口服后>90%被吸收,99%以
Although Bepridil hydrochloride is a calcium channel blocker, its chemical structure is not related to verapamil and nifedipine. Recently, FDA granted oral stable chronic angina pectoris. Because of the potential side effects of this medicine, it is recommended that it be used only when other anti-anginal drugs are intolerant or ineffective. Pharmacological Belipiril, unlike previous calcium channel blockers, blocks both slow and fast sodium channels and simultaneously blocks both voltage-dependent and receptor-initiated calcium channels. After oral administration> 90% is absorbed, 99%