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1989年10月美国首次报告了嗜酸粒细胞增多-肌痛(eosinophilia-myalgia)综合征.该综合征除嗜酸粒细胞增多和肌痛两大症状外,还有皮肤症状在内的多种表现.作者结合文献对皮肤症状进行了介绍.本病系服用色氨酸所致.至1990年5月,美国已报告了1000例以上.1989年美国疾病控制中心(CDC)制定以下诊断标准:(1)末梢血中嘻酸粒细胞数≥1000/mm~3;(2)有妨碍日常生活的剧烈肌痛;(3)除具有(1)、(2)外,无感染及肿瘤等引起的疾病.此病除肌痛外,主要症状还有发热、倦怠感等;并伴有呼吸困难、咳嗽为主的呼吸系统症状;而且出现皮肤症状.皮
The United States first reported eosinophilia-myalgia syndrome in October 1989. In addition to the two major symptoms of eosinophilia and myalgia, there are multiple skin manifestations The authors described the skin symptoms in combination with the literature, which was caused by the use of tryptophan, and reported more than 1,000 cases in the United States by May 1990. In 1989 the Centers for Disease Control and Prevention (CDC) developed the following diagnostic criteria: (1) the number of leptomeninge granulocyte in peripheral blood is more than 1000 / mm ~ 3; (2) there is fierce myalgia which hinder the daily life; (3) it has no infection and tumor besides (1), (2) Of the disease.In addition to myalgia, the main symptoms are fever, fatigue and so on; accompanied by respiratory problems, cough-based respiratory symptoms; and skin symptoms. Skin