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目的:探讨血小板平均体积(MPV)与急性心肌梗死(AMI)患者住院期间并发症之间的关系。方法:回顾性分析AMI患者220例,根据入院时MPV水平四分位分组:Q1组(MPV≤9.62fL),Q2组(MPV 9.79~11.08fL),Q3组(MPV 11.09~12.37fL),Q4组(MPV≥12.38fL)。每组55例,进行AMI并发症发生危险因素的Logistic回归分析;计算不同MPV水平并发症发生风险的优势比。采用二元变量相关分析MPV与凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(FBG)、国际标准化比值(INR)的相关性。结果:AMI患者MPV水平与并发症发生风险之间存在正相关性,调整了年龄、性别、吸烟史、糖尿病、高血压病、血小板其他参数、凝血功能指标、心肌肌钙蛋白(cTnI)、左室射血分数(LVEF)、梗死部位、梗死面积和治疗方式等因素后显示:MPV水平最高四分位数患者发生并发症的风险是最低四分位数患者的1.79倍(95%CI:1.26~2.41,P<0.05)。结论:MPV增高与AMI患者并发症可能密切相关。
Objective: To investigate the relationship between the mean platelet volume (MPV) and the complications during hospitalization in patients with acute myocardial infarction (AMI). Methods: 220 patients with AMI were retrospectively analyzed. According to the quartile of MPV on admission, the patients in Q1 group (MPV≤9.62fL), Q2 group (MPV9.09 ~ 11.08fL), Q3 group (MPV11.09 ~ 12.37fL), Q4 Group (MPV> 12.38 fL). Logistic regression analysis of the risk factors of AMI complications was performed in 55 cases in each group. The odds ratios for the risk of complication were calculated. The correlation between MPV and prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FBG) and international normalized ratio (INR) were analyzed by binary variables. Results: There was a positive correlation between the level of MPV and the risk of complications in AMI patients. Age, sex, smoking history, diabetes mellitus, hypertension, other parameters of platelets, indexes of coagulation function, cardiac troponin (cTnI) Factors such as ventricular ejection fraction (LVEF), infarct size, infarct size, and treatment patterns showed that the highest risk for complication was 1.79 times (95% CI: 1.26) in patients with the lowest quartile of MPV ~ 2.41, P <0.05). Conclusion: The increase of MPV may be closely related to the complication of AMI patients.