论文部分内容阅读
目的:检测急性冠状动脉综合征(ACS)患者血清单核细胞趋化蛋白-1(MCP-1)和干细胞因子(SCF)的变化,探讨MCP-1和SCF与ACS的关系。方法:纳入急性心肌梗死患者41例,不稳定型心绞痛患者45例,对照组32例,应用ELISA法测定其血清MCP-1和SCF的水平。结果:心肌梗死组和心绞痛组MCP-1水平均明显高于对照组(P<0.01和P<0.05)。心肌梗死组及心绞痛组SCF水平略高于对照组,但差异无统计学意义。心肌梗死组MCP-1及SCF水平与血白细胞数、中性粒细胞比率及血脂等水平均无明显相关性。结论:ACS患者尤其是急性心肌梗死患者血MCP-1明显升高,SCF亦有所增加。MCP-1和SCF可能与ACS的发生发展及梗死后的心肌修复有关。
Objective: To detect the changes of serum monocyte chemoattractant protein-1 (MCP-1) and stem cell factor (SCF) in patients with acute coronary syndrome (ACS) and to explore the relationship between MCP-1, SCF and ACS. METHODS: Forty-one patients with acute myocardial infarction, 45 patients with unstable angina pectoris, and 32 control subjects were enrolled in this study. Serum levels of MCP-1 and SCF were measured by ELISA. Results: The levels of MCP-1 in myocardial infarction group and angina pectoris group were significantly higher than those in control group (P <0.01 and P <0.05). SCF levels in myocardial infarction group and angina group were slightly higher than those in control group, but the difference was not statistically significant. The level of MCP-1 and SCF in myocardial infarction group had no significant correlation with leukocyte count, neutrophil ratio and blood lipid level. Conclusion: In patients with ACS, especially in patients with acute myocardial infarction, serum MCP-1 is significantly increased and SCF also increased. MCP-1 and SCF may be related to the occurrence and development of ACS and myocardial repair after infarction.