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目的:前期研究结果发现半夏中大分子淀粉类物质会影响共煎药物中小分子化合物的溶出,拟通过检测半夏、法半夏淀粉的基本物理化学性质来探究炮制对半夏淀粉产生的影响。方法:通过测量半夏和法半夏淀粉的溶解度、润胀度、水结合能力、晶体结构、微观形态来评定炮制对半夏淀粉产生的影响。结果:法半夏和半夏中的淀粉在微观形态上无明显差异,但法半夏淀粉的溶解度、润胀度、水结合能力与半夏淀粉相比显著降低,分别从30.80%,17.22%和10.56降低至13.93%,10.13%和7.82;而结晶度明显提高,半夏淀粉的结晶度31.77%,法半夏淀粉的结晶度55.11%。结论:炮制能影响半夏中淀粉类成分的物理化学性质,推测炮制会对该药物药效产生影响可能与淀粉的性质发生改变有关。
OBJECTIVE: According to the results of previous studies, it is found that the amylaceous macromolecules of Pinellia tuber will affect the dissolution of small molecule compounds in Panax medicament, and the influence of processing on the starch production of Pinellia ternata by probing the basic physical and chemical properties of Pinellia ternata and Pinellia ternata starch . Methods: The effects of processing on the starch production of Pinellia ternate were evaluated by measuring the solubility, swelling degree, water binding capacity, crystal structure and microstructure of Pinellia ternata and Pinellia ternata starch. Results: There was no significant difference in the microscopic morphology of starch in Pinellia ternata and Pinellia ternata, but the solubility, swelling degree and water binding capacity of Pinellia ternata starch decreased significantly from 30.80%, 17.22% And 10.56 decreased to 13.93%, 10.13% and 7.82, respectively; while the crystallinity increased significantly, the crystallinity of Pinellia ternata starch was 31.77% and the crystallinity of Pinellia ternata starch was 55.11%. Conclusion: The processing can affect the physicochemical properties of starch components in Pinellia ternata, suggesting that the influence of processing on the drug efficacy may be related to the change of the properties of starch.