本文作者曾做过大鼠纯一氧化碳(CO)的染毒实验,证明能导致碳氧血红蛋白血症。为获得轻度碳氧血红蛋白血症,本实验采用了浓度为5%的用空气稀释的CO,用皮下注射方法给大鼠投药。预实验证明,空气-CO混合气体的吸收也导致产生碳氧血红蛋白。作者研究了轻度碳氧血红蛋白血症对大鼠运动神经传导速度的影响。取静脉血用IL 182型CO氧化计测碳氧血红蛋白水平,然后腹腔注射己巴比妥,用Glatzel氏法于室温(24±10℃)测坐骨神经传导速度。实验结果用t测验进行统计处理。实验结果表明,皮下注射0.12 mM CO/kg体重导致出现的碳氧血红蛋白最高值为9(6～12)%,并且使神经传导速度降低了16%左右;这一效应延续四周 The authors of this study have done experiments on exposure to pure carbon monoxide (CO) in rats and have been shown to cause carboxyhemoglobinemia. In order to obtain mild carboxyhemoglobinemia, we used CO at a concentration of 5% diluted with air and administered subcutaneously to rats. Preliminary experiments show that the absorption of air-CO mixture also leads to carboxyhemoglobin. The authors studied the effect of mild carboxyhemoglobinmia on motor nerve conduction velocity in rats. Venous blood was taken for measurement of carboxyhemoglobin level by CO oxidation of IL 182 type, followed by intraperitoneal injection of hexobarbital. Sciatic nerve conduction velocity was measured by Glatzel’s method at room temperature (24 ± 10 ° C). Experimental results using t test for statistical processing. The experimental results showed that subcutaneous injection of 0.12 mM CO / kg of body weight resulted in a peak of carboxyhemoglobin of 9 (6-12)% and reduced nerve conduction velocity by about 16%; this effect continued for four weeks