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维持适当的氧含量对机体的生存至关重要,但是在许多病理情况下,细胞和组织器官经常会处于一种缺氧的状态,此时细胞需要通过缺氧诱导因子(hypoxia-inducible factors,HIF)途径来适应缺氧的环境。肿瘤细胞的过度生长会限制肿瘤内的氧气弥散,导致肿瘤内血液供应不足,产生缺氧的微环境,进而促进HIF的表达。HIF具有广泛的下游基因,与多种信号通路有关,参与肿瘤血管的形成、维持肿瘤干细胞的稳定、促进肿瘤转移,并与肿瘤的预后相关,在肿瘤的发生发展中起到至关重要的作用,有望为肿瘤的精准治疗提供新的靶点和思路。
Maintaining proper oxygen levels is vital to the survival of the body, but in many pathological conditions cells and tissues and organs often end up in an anoxic state where cells need to pass hypoxia-inducible factors (HIFs) ) Ways to adapt to the hypoxic environment. Overexpression of tumor cells limits the diffusion of oxygen within the tumor, resulting in inadequate blood supply within the tumor, resulting in hypoxic microenvironment, which in turn promotes HIF expression. HIF has a wide range of downstream genes, which are involved in various signal pathways, participate in the formation of tumor blood vessels, maintain the stability of tumor stem cells and promote tumor metastasis, which is related to the prognosis of the tumor and plays a crucial role in tumor development , Is expected to provide a new target for accurate treatment of cancer and ideas.