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目的 :比较脑梗死 (CI)及多梗死性痴呆 (MID)患者脑脊液 (CSF)中肿瘤坏死因子 α(TNF α)含量的变化。方法 :采用放射免疫分析法测定 72例CI、5 5例MIDCSF中TNF α含量 ,以 3 2例正常人为对照。结果 :CSF中TNF α的含量在MID急性发作组、CI急性期同对照组及CI恢复期比较均显著增高 (P <0 0 1) ;MID稳定期组同对照组相比明显增高 (P <0 0 5 ) ,同CI恢复期相比无显著差异(P >0 0 5 )。CSF中TNF α的含量与MMSE评分无显著相关 (P >0 0 5 )。结论 :CSF中TNF α含量与CI病理机制明显相关 ,但与MID的认知功能下降无显著相关
Objective: To compare the changes of tumor necrosis factor α (TNF α) in cerebrospinal fluid (CSF) of patients with cerebral infarction (CI) and multi-infarct dementia (MID) Methods: Radioimmunoassay was used to determine the content of TNFα in 72 cases of CI and 55 cases of MIDCSF, with 32 healthy controls as controls. Results: The levels of TNFα in CSF were significantly increased in acute exacerbation group (MID), acute exacerbation of CI group and control group (P <0.01), and were significantly increased in MID stable group compared with control group (P < 0 0 5), no significant difference compared with CI recovery period (P> 0 0 5). There was no significant correlation between the levels of TNFα in CSF and MMSE scores (P> 0.05). Conclusion: There is a significant correlation between the level of TNFα in CSF and the pathological mechanism of CI, but not with the decrease of cognitive function in MID