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本文报告20例大肠癌中的MMA反应情况。其中结肠癌11例,直肠癌9例,均属中、晚期大肠癌。与对照组77例比较,肿瘤大体形态、浸润深度、组织学类型均无明显差异。MMA主要见于肿瘤性腺体旁和腔内,特别在腺体结构破坏、腔膜面直接与间质相连的区域多见。MMA胞浆内可见吞噬的瘤细胞,提示HMA可能是对肿瘤的免疫反应。在分化的腺癌中常见MMA反应,而在未分化癌中未见,可能与肿瘤抗原的含量有关。伴MMA反应的大肠癌病例淋巴结转移较对照组少.且各年生存率均高于对照组,表明MMA反应对大肠癌的生物学行为有一定影响。
This article reports on the MMA response in 20 cases of colorectal cancer. There were 11 cases of colon cancer and 9 cases of rectal cancer, all of which were middle and late stages of colorectal cancer. Compared with 77 cases in the control group, there was no significant difference in the gross morphology, depth of invasion, and histological type of the tumor. MMA is mainly found in the paraneoplastic and intraluminal regions of the tumor, especially in the regions where the gland structure is destroyed and the luminal surface is directly connected with the mesenchyme. The phagocytosis of tumor cells was observed in the cytoplasm of MMA, suggesting that HMA may be an immune response to tumors. MMA reactions are common in differentiated adenocarcinomas but not in undifferentiated carcinomas and may be related to the content of tumor antigens. The lymph node metastasis of colorectal cancer with MMA reaction was less than that of the control group, and the survival rate in each year was higher than that in the control group, indicating that the MMA reaction has a certain influence on the biological behavior of colorectal cancer.